Metal-Based Drug-DNA Interactions

Metal-Based Drug-DNA Interactions

Coordination compounds that bind to DNA have been an active area of research since the discovery of cisplatin and the platinum based drugs. In this review we offer a general overview about transition-metal compounds that binds DNA through several ways and some examples are given to understand the role played by the different factors that promotes it, such as the intercalant ligand and the natur...

Metal–DNA interactions

Metal ions can bind to DNA directly or indirectly through hydrogen bonding of the coordinating water molecules surrounding the metal ions. Metal binding to the bases usually disrupts base pair hydrogen bonding and destabilizes the double helix. Spectroscopic and X-ray data shows that the N7 atom of the purine or N3 of pyrimidine residues as well as exocyclic O atoms and the phosphate oxygen ato...

Interactions of metal ions with DNA

Significant drug interactions in dermatology

Systemic drugs have been used widely in the treatment of many skin diseases. Although dermatologists are familiar with the guidelines of selecting appropriate patients and prescribing systemic drugs, their knowledge about the side effects and significant interactions of systemic drugs used in dermatology is more limited. So a short review on important drug interactions seems to be useful. Some ...

A theoretical study on interactions between Berberine as an anticancer drug and DNA

In this study, we present the work on the physicochemical interaction between the anti-cancer alkaloidberberine (BRB) and DNA with the purpose of designing drugs that interact more with DNA. Molecularmodeling on the complex formed between berberine and DNA presented that this complex was undeniablyfully able of participating in the formation of a stable intercalation site. Besides, the molecula...